Liver and aging, 1978 proceedings of the Tokyo Symposium "Liver and Aging, 1978" held in Tokyo, Japan on August 27-28, 1978, a satellite symposium of the 11th International Congress of Gerontology by Tokyo Symposium "Liver and Aging, 1978".

Cover of: Liver and aging, 1978 | Tokyo Symposium

Published by Elsevier/North-Holland Biomedical Press, sole distributors for the USA and Canada, Elsevier North-Holland in Amsterdam, New York, New York .

Written in English

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Subjects:

  • Liver -- Aging -- Congresses.,
  • Liver cells -- Congresses.,
  • Liver -- Effect of drugs on -- Congresses.,
  • Aging -- Congresses.,
  • Liver -- Physiology -- Congresses.,
  • Aging -- Congresses.

Edition Notes

Includes bibliographical references and index.

Book details

Statementeditor, Kenichi Kitani.
GenreCongresses.
ContributionsKitani, Kenʼichi., International Congress of Gerontology (11th : 1978 : Tokyo, Japan)
Classifications
LC ClassificationsQP185 .T64 1978
The Physical Object
Paginationxi, 388 p. :
Number of Pages388
ID Numbers
Open LibraryOL4735137M
ISBN 100444800883
LC Control Number78024443

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Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (K), or click on a page image below to browse page by Liver and aging 9. Europe PMC is an ELIXIR Core Data Resource Learn more >.

Europe PMC is a service of the Europe PMC Funders' Group, in partnership with the European Bioinformatics Institute; and in cooperation with the National Center for Biotechnology Information at the U.S.

National Library of Medicine (NCBI/NLM).It includes content provided to the PMC International Cited by: 9. This book was perfect for that purpose. It contains lots of general information on the liver and how it works.

It gives a brief outline of most common diseases affecting the liver and their treatment in general.4/4(11). The effects of liver disease and aging on the disposition of diazepam, chlordiazepoxide, oxazepam and lorazepam in man - WILKINSON - - Acta Psychiatrica Scandinavica - Wiley Online Library The effects of liver disease and aging on the disposition of diazepam, chlordiazepoxide, oxazepam and lorazepam in manCited by: It's The Liver Stupid: An Anti-aging and Healing Art That Really Works [Clark, Mr.

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Berkson's book is full of specifics/5(). After spending more than 10 years on liver and aging (Kitani,b), I realized and now am convinced that many if not 1978 book liver functions, especially enzyme activities, stay unchanged with age, as long as the subjects remain by: The ability of the liver to metabolize many substances decreases with aging.

Thus, some drugs are not inactivated as quickly in older people as they are in younger people. As a result, a drug dose that would Liver and aging have side effects in younger people may have dose-related side effects in older people (see Aging and Drugs).

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Sandra Cabot has devoted her career to helping people heal themselves from this potentially fatal yet still. The effects of liver disease and aging on the disposition of diazepam, chlordiazepoxide, oxazepam and lorazepam in man. WILKINSON. af>Department of Pharmacology. Vanderbilt University, School of Medicine.

Nashville. Tokyo Symposium "Liver and Aging, ". Liver and aging, Amsterdam ; New York: Elsevier/North-Holland Biomedical Press ; New York: sole distributors for the USA and Canada, Elsevier North-Holland, (OCoLC) Material Type: Conference publication, Internet resource: Document Type: Book, Internet Resource: All Authors.

Full text Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (K), or click on a Cited by: 9. Liver and aging. Conclusions. In conclusion, available data are not sufficient to conclude that ageper se compromises liver functions in general as long as subjects maintain their health.

This does not mean, however, that livers in the elderly can always function as efficiently as those in the by: Random book my mom lent me about the healing powers of alpha lipoic acid.

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Aging is associated with the severity and poor prognosis of various liver diseases including nonalcoholic fatty liver disease, alcoholic liver disease, hepatitis C, and liver transplantation.

Summary Treatment of older patients with liver disease may Cited by: cirrhosis (sərō´səs), degeneration of tissue in an organ resulting in fibrosis, with nodule and scar term is most often used in relation to the liver, because that organ is most often involved in cirrhosis.

Cirrhosis of the liver interferes with the liver's metabolism of nutrients, detoxification of the blood, bile production, and other normal functions (see liver); its.

Core tip: Nonalcoholic fatty liver disease (NAFLD) is a common disease in the elderly, in whom it follows a more severe course due to worse hepatic and extrahepatic manifestations.

The former include nonalcoholic steatohepatitis and hepatocellular carcinoma; the latter include cardiovascular and metabolic by: The rising concern with the medical effects of aging and also its action on the liver has been created not by such factors but rather by sociologic concerns, namely by the rapid increase of the aged segment of the population as expressed in demographic data (U.N.

World Assembly ; Butler and Beam ).Cited by: 1. If antioxidant enzyme activities are lowered during aging.

it may further accelerate the aging processes, in fact, Reis and Gershon () have shown that superoxide dismutase (SOD) activities in the liver significantly decline with age in by: In autopsy studies, aging was found to be associated with a 24% reduction in liver weight in males and a 18% reduction in females.

This trend has been confirmed with different techniques (Table 3) and in general, the reduction of liver size is noted to be in the order of 25–35% (Le Couteur and McLean, ).Cited by: 9.

The Impact of Aging on the Liver Introduction The liver is a resilient organ that maintains its homeostatic functions with age. Rou-tine tests of liver function (serum bilirubin, serum albumin, aminotransferases, alka-line phosphatase and INR) remain normal File Size: 27KB.

: Liver And Aging Liver and Drugs (): Kitani: Books Books Go Search Hello Select your address Best Sellers Customer Service New Releases Whole Foods Find a Gift Author: Kitani. Lopez-Torres, M., Gredilla, R., Sanz, A.

and Barja, G., Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria.

Free Radic Biol – PubMed CrossRef Google ScholarCited by: 5. Generally, the experience of accelerated aging can be seen medically, physically and functionally. Many family members and caregivers commonly observe that people with Down syndrome appear to “slow down” once they enter their late 40s or 50s.

Complicating this picture is that “normal aging” in adults with Down syndrome is still not. Effects of aging and liver disease on disposition of lorazepam. Kraus M.D. Comparison of lorazepam's systemic plasma clearance in the liver disease patients in whom studies with antipyrine and chlordiazepoxide had also been performed indicated impairment in their values but this was not the case for lorazepam.

Aging also does not Cited by: Zürcher C, Van Zwieten MJ, Solleveld HA, Van Bezooijen CFA, Hollander CF () Possible influence of multiple pathological changes in aging rats on studies of organ aging, with emphasis on the liver. In: Kitani K (ed) Liver and Aging - - Liver and Drugs, Proc.

Second Tokyo Symposium on Liver and Aging - Liver and Drugs, Tokyo, Japan Cited by: 5. This chapter focuses on the infrared studies of acid phosphatase isoenzyme I age-related alterations in rat liver. Acid phosphatase from rat liver is an enzyme that hydrolyzes the phosphomonoester bonds of wide variety of molecules at acid pHs.

It occurs in two molecular forms, namely, isoenzyme I and II, which have molecular weight around Author: Jacek Twardowski. A change in drug clearance with age is considered an important factor in determining the high prevalence of adverse drug reactions associated with prescribing medications for the elderly.

Despite this, no general principles have been available to guide drug administration in the elderly, although a substantial body of clearance and metabolism data Cited by: The aim of this study was to determine the effect of aging upon liver volume and apparent liver blood flow in healthy man.

Sixty-five subjects between 24 and 91 years of age were recruited. Liver regeneration is compromised in old animals and in elderly humans.

The rate of liver regeneration, rather than the regenerative capacity, is diminished in the elderly. The induction of hepatocyte proliferation factors and the expression of Cited by: Biochemical Pharmacology, Vol. 34, No. 4, pp.Printed in Great Britain.

^/85 $ + Pergamon Press Ltd. SHORT COMMUNICATIONS Disappearance of sex difference in rat liver drug metabolism in old age (Received 30 March ; accepted 13 August ) It has been known that age and sex are two important determinants of hepatic Cited by: Many organ systems exhibit significant age-related deficits, but, based on studies in old rodents and elderly humans, the liver appears to be relatively protected from such changes.

A remarkable feature of the liver is its capacity to regenerate its mass following partial hepatectomy.

Reports suggests that aging compromises the liver's regenerative capacity, both in the rate and to the Cited by: Schmucker DL, Jones AL, Mills ES () Morphometric analysis of the ultrastructural changes in the liver of aging rats. J Gerontol – PubMed Google Scholar Pharmacodynamic Changes With Aging Impaired homeostatic capacity, which is part of physiology of aging and changes in liver and kidney metabolism, translates into increased sensitivity to various medications in the elderly.

Important classes of medications include anticoagulants, antihypertensive medications, antipsychotics, and sedatives. A Healthy Liver is Key to Effective Aging. When people want to slow down the aging process maintaining a healthy liver is not something they think about. Usually they think about the health of their heart, skin, and brain.

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